Empreses emergents
2024
ALLOSTERY EXPLORATION TECHNOLOGIES SL (Allox)Tecnologia de plataforma patentada capaç de cartografiar i trobar llocs al·lostèrics en proteïnes rellevants per a malalties. El descobriment d'aquests nous llocs al·lostèrics obrirà el camí per al disseny i desenvolupament de nous fàrmacs selectius.
Adreça
Carrer de Roc Boronat 70, 08005 Barcelona, Espanya
Dades financeres
Propietat CERCA
Barcelona, Spain
2000
Centre de Regulació Genòmica (CRG)
Àrees d'estat i deeptech
Estat de l'empresa i àrees de tecnologia profunda de l'empresaEstat de l'empresa
Àrea DeepTech
Informació sobre la spin-off
Descripció de l'empresa
ALLOX is mapping allosteric switches in proteins that cause disease and then designing medicines to turn them off.This strategy massively expands the universe of druggable targets and accelerates therapeutic development.
Descripció del producte
The ALLOX platform is based on ‘multidimensional mutagenesis’, an experimental method developed in the lab of Ben Lehner, that allows measuring the activity of as many as 1 million mutant versions of a protein in a single experiment. The method can directly link genetic changes to phenotypical and biophysical measurements, which is unprecedented. This method allows the company to scan through, at the protein sequence level, and identify new allosteric pockets. Different from other methodologies, it is scalable, quick, and cost-efficient. Further, the unprecedented scale of biophysical measurements generated by the experimental ALLOX platform will lay the foundation for developing AI algorithms to expand drug development efforts.
ALLOX’s main focus is currently within oncology, but the platform has the potential to be exploited for many other relevant diseases.
ALLOX’s main focus is currently within oncology, but the platform has the potential to be exploited for many other relevant diseases.