GINYS-CRG-007

Tissue engineering

The goal of the Tissue Engineering Platform is to provide the CRG, PRBB and external researchers with the latest technologies used in the fields of stem cell biology, stem cell differentiation, organoid formation and induced pluripotent stem cells (iPSC). The Unit is constantly implementing new technologies that are emerging in the previous areas. The tissue engineering platform works in collaboration with the CRG’s Biomolecular Protein and Screening Technologies Unit to offer the CRISPR / Cas9 genome editing technology service. Since 2020, the Tissue Engineering Unit also includes the Internal Histology Service (only for PRBB residents). The Internal Histology Service was created in 2007 to provide the CRG with the histopathological analysis needed to analyze tissues based on research conducted in in vivo models. Studies of tissue developmental biology, homeostasis, and pathology require an in-depth analysis of the morphological and molecular characteristics of tissues and the alterations produced by manipulation. A common tool for these studies is to generate animal models that can recapitulate a specific process or a specific disease. Subsequently, histological and immunohistological analyzes are required to identify and characterize changes in cytoarchitecture and tissue morphology. Immunohistochemistry is an essential tool for determining the location of proteins and RNA at the cellular and tissue level. In this sense, the main objective of the Internal Histology Service is to perform and optimize the processing and histological analysis of the tissue, based on experimental animal models and of human origin. The service also offers advice and training in common histological techniques, in close collaboration with the different groups of the CRG.

GINYS-CRG-006

Bioinformatics

The Bioinformatics Unit offers researchers from the CRG-CNAG / PRBB and external organizations consulting services, NGS planning and other genomic experiments, NGS data processing, analysis and management, software and database development, training in bioinformatics and access to high performance computing resources. to the CRG. The Unit works in synergy with the Genomics Unit and the Biomolecular Protein and Screening Technologies Unit (BMS-PT) to support users using high-throughput sequencing technologies, from planning an experiment to delivery of timely and reliable results

GINYS-CRG-005

Genomics

The CRG Genomics Core Facility was established in 2008 and currently supports next-generation sequencing technologies. Since its founding, the CRG has made significant investments in genomics, including the purchase of several next-generation sequencing instruments. Several high-throughput technologies have been implemented to evaluate differential expression, interindividual genetic variation, microRNA discovery, genome sequencing, targeted resequencing, epigenetic profiling, and DNA binding site identification. or RNA-associated proteins.

GINYS-CRG-004

Proteomics

The Proteomics Unit is a joint effort of Pompeu Fabra University and the Center for Genomic Regulation to create an innovative research infrastructure with a high level of excellence and sustainability to support scientists in the biomedical field. As part of the Spanish National Omics Infrastructure ICTS OmicsTech (www.omicstech.es), the Proteomics Unit is a national reference unit for proteomics analyses. The Unit's activities focus on providing high-quality proteomics services with strong added value to the research community through: Advice, expertise and experience in proteomics analyses Development of new methods and facilitating techniques for cutting-edge research and innovation Training and the active dissemination of new methods and scientific advances in the field of proteomics

GINYS-CRG-003

Protein technologies

The Biomolecular and Protein Screening Technologies Unit (BMS & PT) offers CRG-CNAG / PRBB researchers, external institutions and private companies a new high-quality technological platform to carry out the production of proteins and automated processes in the context of biomolecular and biochemical screening assays. Through staff-assisted detection, users will have access to facility equipment, including liquid handlers, plate readers, and small molecule libraries. In addition, the unit aims to support CRG institute researchers by purchasing, researching, and maintaining valuable stocks of clones and strains.

GINYS-CRG-002

Flow cytometry CRG / UPF

The Flow Cytometry Unit is a joint unit between Pompeu Fabra University and the Centre for Genomic Regulation with the aim of creating an innovative infrastructure of excellence and support for biomedical research.The Unit has the resources to develop any of Cytometry applications, it also provides the necessary scientific and technical support, as well as the necessary training for the design, supervision and development of the applications required by the researchers.

GINYS-CRG-001

Advanced light microscopy unit

It is the aim of this unit to provide instruments covering the whole application spectrum of advanced light microscopy and to make them available to researchers from the CRG as well as for visitors from other research institutions. As Core Facility for light microscopy, the unit provides a number of advanced light microscopy systems, equipment for sample preparation and maintenance prior to imaging and resources for the subsequent processing of the image data. The staff assists researchers in the experimental planning of light microscopy experiments and provides the in-depth training for the operation of the microscopes and for specific imaging techniques. Additionally, support is provided in the processing, rendering and analysis of the acquired datasets. If needed, custom analysis routines will be designed.

Engineering Mycoplasma species for biotechnological and biomedical applications

Ariadna Montero Blay

Regulation of NUMB alternative splicing by RBM10 and control of cancer cell proliferation

Jordi Hernández Ribera