2016-01-002 - HH-LAB - Compact device for in vitro and in vivo hybrid magneto-thermal and photo-thermal therapies

HH-LAB

2016-01-002

Magnetic and optical heating efficiency in colloidal dispersions of magnetic, plasmonic and magneto-plasmonic nanoparticles. Magneto-thermal and photo-thermal effects in cell cultures

Local magnetic and optical hyperthermia using magnetic nanoparticles and high frequency magnetic fields, and nanoparticles with high optical absorption (plasmonic nanoparticles, carbon nanotubes…) and light, respectively, are active research fields for the development of localized thermal treatments with the aim of directly killing cancer cells, or acting as adjuvants to improve the efficacy of chemotherapeutic drugs. Both magneto-thermal and photo-thermal therapies using different nanoparticles are currently under clinical trials. However, both magnetic and optical hyperthermia treatments have important limitations. In the case of magnetic hyperthermia, to achieve the necessary temperature increase, very high particle concentrations (> 1 mg/mL) are required, in combination with high intensity and high frequency magnetic fields, which can be over the recommended safety values for humans. On the other hand, the main limitation of local photo-thermal therapies with nanoparticles is the low penetration depth of light in the tissue. Even for near infrared light in which the absorption of tissues is minimized, the penetration depth is below 1 cm. Therefore, there is currently the need to provide commercial devices suitable for local hyperthermia using safer and more effective actuation conditions, which could be applied for in vitro and in vivo applications. To overcome these limitations, ICN2 Magnetic Nanostructures’s Grup have developed a laboratory prototype that enables simultaneous magnetic and optical actuation on nanoparticles to enhance their local heat generation and, consequently, their efficiency for local hyperthermia nanotherapies with smaller particle concentrations, lower field intensities and in deeper tissue.

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The aims of this GINJOL project was licensing-out the HH-LAB device, and stablish joint development agreements for its industrial development.

The market has been already assessed and main niches detected are universities, hospitals and research institutions working in nanomaterials, photo-thermal therapies, magneto-thermal therapies, theranostics or drug delivery. Geographically, the main markets are: USA, China, Europe, India, Japan, Korea, and Canada

Life Science, Oncology treatment

In order to hav a successful commercialisation there’s the need of preforming a Freedom to Operate analysis, after the first EPO examination (February 2017). Depending on those results, the KTT department would evaluate the possibility of give non-exclusive licenses, contacting other of the detected (identified) companies.

An external valorisation study in order to set the price for the license fee and its development (market oriented consultancy). Specialized lawyers advice (legal consultancy).

ICN2 Magnetic Nanostructures’s Grup have developed a laboratory prototype that enables simultaneous magnetic and optical actuation on nanoparticles to enhance their local heat generation and, consequently, their efficiency for local hyperthermia nanotherapies with smaller particle concentrations, lower field intensities and in deeper tissue.

Not yet a real current market. Early technology

ICN2 planned route to exploit this technology is via licensing the patent application. Our commercialisation target is a company, such as NanoTherics, Nanoscale Biomagnetics, Ambrell Induction Heating Solutions, Fives Celes and MSI Automation, able to scale up the production, produce and sell this device to different research laboratories.

Abandoned

Know-How on personalized medicine, data analytics and genomics

Patents: WO2018002043A3 - PCT/EP2017/065842 - Date: May 31st, 2018 Status: Granted URL: https://patents.google.com/patent/WO2018002043A3/en

Compared to other commercial devices, it is possible to integrate photo and magneto-thermal therapies.