HTE – High throughput experimentation

The High Throughput Experimentation (HTE) laboratory is dedicated to running a large number of reactions and analyzing them in a short period of time with the intention of accelerating the discovery processes; discovery of new reactions, new products or new reaction conditions. The facility is configured to run different types of reactions in 24- or 96-well plates, including those that are air-sensitive, reactions with reactive gases, photochemical reactions or reactions under pressure conditions. In addition, the Laboratory has a large number of reagents, solvents, metals and ligands to carry out the reactions. Regarding the analysis of the reactions, the laboratory is equipped with state-of-the-art chromatographs.

Facility

Images

300 MHz NMR Spectrometer

High speed NMR spectrometer to measure 13C and 1H, equipped with a 60 position autosampler

GC-MS

Gas chromatograph coupled with a MS detector from Agilent. The device has a high capacity autosampler to work with several 96 analysis plates at the same time

Glove Box train

Last generation glove box from MBraun with sixteen gloves. It’s a space to work under inert conditions that allows the storage of reagents and to set up, run and treat reactions. The box has several connections to provide services in the box: nitrogen flow, vacuum, chiller and electrical connections.

Parallel Centrifugal Evaporator

EZ-II Elite from Genevac. Device to evaporate the content of two 96 well plates at the same time, with the capability to evaporate solvents with boiling points up to 189ºC.

Pressure reactors

Reactors to run reactions under pressure conditions using 96 well plates.

SFC chromatograph

Supercritical CO2 chromatograph coupled with a DAD detector and the possibility to be coupled also with a MS detector and equipped with an autosampler to handle two 96 analysis plates. UPC2 from Waters.

Tumble stirrers

Highly efficient stirrers that ensure the perfect stirring of all the positions in 96 well plates.

UHPLC chromatograph

UHPLC coupled with DAD and MS detectors and an autosampler that handles two 96 analysis plates. Acquity from Waters

Well plates

A wide collection of 96 and 24 well plates to run reactions under different conditions.

Institutional Contacts / Head of Facilities

GC

Gisela Colet
Institut Català d'Investigació Química (ICIQ)

Provisional Contacts

Dr. Xisco Caldentey | Manager |  xcaldentey@iciq.es  | 977 920 200 (ext. 342) |  ORCID 

Manager

Dr. Xisco Caldentey | Manager |  xcaldentey@iciq.es  | 977 920 200 (ext. 342) |  ORCID 

Dr. Gisela Colet | Facilities Coordinator |  gcolet@iciq.cat  | Phone: +34 977 920 238

CERCA Institutes

Tarragona, Spain

2004

Institut Català d'Investigació Química (ICIQ)

Owners

Centres CERCA List

Address

https://iciq.org/research-unit/cellex-iciq-hte-laboratory/

Equipments & Services Offered

Train of glove boxes for storing chemicals and preparing sensitive reactions under inert atmosphere Pipettes: single and multiple channel Aluminum reaction blocks with ANSI/SLAS format Photochemical reactors Pressure reactors Stirrers and shakers Heating/cooling devices ANSI/SLAS format Automatic solids dispensing system UHPLC-MS/DAD (Waters) SFC-DAD/MS (Waters) GC-MS/FID (Agilent) Large capacity auto samplers on all chromatographs Wide range of chromatographic columns available, including chiral

• Rapidly examine arrays of conditions (catalysts, reagents, solvents…) with minimal material consumption • Rapid ligand screening • Process optimization • Optimize individual steps in a synthesis • Discovery of new methodology • Generate molecular diversity • Late-stage functionalization of an active ingredient • Structure–activity relationship

Categorització

RIS3CAT domains & other

RIS3CAT Domains
CERCA GINYS Categories

GINYS-ICIQ-007

Access procedure & Fares

Send an e-mail to the Unit staff.

https://iciq.org/wp-content/uploads/2025/08/RSA-01-2025_ENG.pdf

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