New generation sequencing for HIV genotyping

Tests include genotypic antiretroviral resistance determination in reverse transcriptase, protease and integrase as well as genotypic HIV tropism testing. Resistance is usually determined from plasma, but can also be determined from PBMCs or low-viral- load plasma (ultracentrifugation) for patient with low viral loads or with non-evaluable results. The service, launched in 1999, was designated a reference centre for antiretroviral resistance testing by the Catalan Health Service in 2002. It also participates in research projects and clinical trials with other institutions and pharmaceutical companies

Facility

Images

Provisional Contacts

Main Contact(s) of Facility

Staff

Head of facilities

CERCA Institutes

Badalona, Spain

1995

Institut de Recerca de la Sida (IRSICAIXA)

Owners

Centres CERCA List

Address

Link

https://www.irsicaixa.es/en/research

Equipments & Services Offered

Equipments

NSG Worflow Sentosa SX101 Sentosa ST401i i ST401e Sentosa SQ301 Sentosa SQ Reporter Miniplate spinner Pipetes

Services

Sequencing Service

Categorització

RIS3CAT domains & other

Domains

RIS3CAT Domains

CERCA GINYS Categories

CERCAGINYS code

GINYS-IRSICAIXA-001

Access procedure & Fares

Access procedure

Open. Contact the person responsible for the service via email.

Availability

Official fares & Access

https://ginys.cerca.cat/wp-content/uploads/2022/12/Tarifes_GINYS-IRSICAIXA-001_1-2.pdf

Papers

Viral evolution during structured treatment interruptions in chronically human immunodeficiency virus-infected individuals

Martinez-Picado J, Frost SD, Izquierdo N, Morales-Lopetegi K, Marfil S, Puig T, Cabrera C, Clotet B, Ruiz L.

CERCA GINYS Papers

Genotypic and phenotypic evolution of HIV type-1 protease during in vitro sequential or concomitant combination of atazanavir and amprenavir

Cunyat F, Ruiz L, Marfil S, Puig T, Bofill M, Blanco J, Clotet B, Cabrera C.

CERCA GINYS Papers

RECall for automated genotypic tropism testing

Pou C, Bellido R, Casadellà M, Puig T, Clotet B, Harrigan R, Paredes R.

CERCA GINYS Papers

Inhibition of herpes simplex virus type 1 by the CDK6 inhibitor PD-0332991 (palbociclib) through the control of SAMHD1.

Badia R, Angulo G, Riveira-Muñoz E, Pujantell M, Puig T, Ramirez C, Torres-Torronteras J, Martí R, Pauls E, Clotet B, Ballana E, Esté JA.

CERCA GINYS Papers

The G1/S Specific Cyclin D2 Is a Regulator of HIV-1 Restriction in Non-proliferating Cells.

Badia R, Pujantell M, Riveira-Muñoz E, Puig T, Torres-Torronteras J, Martí R, Clotet B, Ampudia RM, Vives-Pi M, Esté JA, Ballana E.

CERCA GINYS Papers

Long-term HIV-1 infection induces an antiviral state in primary macrophages

Pujantell M, Badia R, Ramirez C, Puig T, Clotet B, Ballana E, Esté JA, Riveira-Muñoz E.

CERCA GINYS Papers

RNA editing by ADAR1 regulates innate and antiviral immune functions in primary macrophages

Pujantell M, Riveira-Muñoz E, Badia R, Castellví M, Garcia-Vidal E, Sirera G, Puig T, Ramirez C, Clotet B, Esté JA, Ballana E.

CERCA GINYS Papers

Evaluation of the Innate Immune Modulator Acitretin as a Strategy To Clear the HIV Reservoir

Garcia-Vidal E, Castellví M, Pujantell M, Badia R, Jou A, Gomez L, Puig T, Clotet B, Ballana E, Riveira-Muñoz E, Esté JA.

CERCA GINYS Papers

Evolution of drug resistance in HIV-infected patients remaining on a virologically failing combination antiretroviral therapy regimen

Alessandro Cozzi-Lepri 1 , Andrew N Phillips, Lidia Ruiz, Bonaventura Clotet, Clive Loveday, Jesper Kjaer, Helene Mens, Nathan Clumeck, Ludmila Viksna, Francisco Antunes, Ladislav Machala, Jens D Lundgren, EuroSIDA Study Group

CERCA GINYS Papers

Prevalence of transmitted antiretroviral resistance and distribution of HIV-1 subtypes among patients with recent infection in Catalonia (Spain) between 2003 and 2005.

Romero A, Sued O, Puig T, Esteve A, Pumarola T, Casabona J, González V, Matas L, Tural C, Rodrigo I, Margall N, Domingo P, Casanova A, Ferrer E, Caballero E, Ribera E, Farré J, Puig T, Amengual MJ, Navarro G, Prat JM, Masabeu A, Simó JM, Villaverde CA, Barrufet P, Sauca MG, Ortin X, Ortí A, Navarro R, Euras JM, Vilaró J, Villà MC, Montull S, Vilanova C, Pujol F, Díaz O, Miró JM; AERI study Group.

CERCA GINYS Papers

Prevalence of genotypic resistance to nucleoside analogues and protease inhibitors in Spain. The ERASE-2 Study Group

Puig T, Pérez-Olmeda M, Rubio A, Ruiz L, Briones C, Franco JM, Gómez-Cano M, Stuyver L, Zamora L, Alvarez C, Leal M, Clotet B, Soriano V.

CERCA GINYS Papers

Comparison of the LiPA HIV-1 RT test, selective PCR and direct solid phase sequencing for the detection of HIV-1 drug resistance mutations.

Schmit JC a, Ruiz L , Stuyver L , Van Laethem K , Vanderlinden I , Puig T , Rossau R , Desmyter J , De Clercq E , Clotet B , Vandamme AM

CERCA GINYS Papers

Institutional Quality

HRS4R

Human Resource Strategy for Researchers It supports research institutions and funding organizations in implementing the Charter and Code in their policies and practices. The implementation of the Charter and Code principles by research institutions makes them more attractive to researchers looking for a new employer or host for their research project..

Roger CabezasUnitat de TransferènciaI-CERCA

CERCA GINYS Quality

Code of Conduct CERCA

The CERCA Code of Conduct, aligned with the European Code of Conduct for Research Integrity, recognized by the European institutions, provides guarantees in terms of transparency, open access to data and results, industrial property management, scientific integrity and relationship with the media, among others.

Roger CabezasUnitat de TransferènciaI-CERCA

CERCA GINYS Quality

EQA

External quality assessment program (EQA)

Roger CabezasUnitat de TransferènciaI-CERCA

CERCA GINYS Quality