GINYS-IISPV-004

Metabolomics Facility

The Metabolomics Platform is a joint research facility created by URV (Universitat Rovira i Virgili, Tarragona, Spain) and CIBERDEM (Spanish Biomedical Research Network in Diabetes and Associated Metabolic Disorders). The Metabolomics Platform is part of IISPV (Pere Virgili Health Research Institute), a major medical research organization that undertakes numerous research initiatives in the country. The main goal of the Metabolomics Platform is to offer metabolomic services to the biomedical and clinical research groups from CIBERDEM and URV. The main vision of the Metabolomics Platform is not only act as a measurement facility but to offer metabolic consulting, trying to get fully involved in the metabolic-related experiments proposed by the groups. This means that the collaboration should start from the very beginning of the study (definition of goals, dimension and characteristics of the sample set, metabolic experimental design) until the very end (data processing and interpretation), helping to obtain sound, significant and useful clinical results for the different research groups willing to use the facility services. The equipment available in high field NMR allows high throughput analytical measurements of body fluids i.e., serum, urine as well as tissue or biopsies analysis of humans and/or animal models (i.e., rats, mice, etc.). The use of advanced statistical, chemometric, multivariate and artificial intelligence algorithms will allow turning large measurement datasets into useful clinical information. These techniques allow performing what is generally known as metabolic fingerprinting or profiling. The diagnosis of metabolic related illnesses and risk evaluation on large population studies, are the major concerns of the platform together with the identification of metabolic pathways or involved biomarkers in metabolic related diseases. Although specially addressed to the needs of CIBERDEM and URV groups, the Metabolomics Platform welcomes any biomedical

GINYS-IISPV-003

Histological, cytological and digitization studies unit

The platform is cross-cutting and supports research through histological and cytological studies, which also facilitates immunohistochemical, immunocytochemical and immunofluorescence, in situ and molecular hybridization studies. It also offers the possibility of digitizing images digital microscopy studies and image analysis.

GINYS-IISPV-002

Cytometry

Flow cytometry studies the optical parameters emitted by particles (cells, cell fractions). Flow cytometers can study a series of individual particle parameters simultaneously, rapidly, and over a large number of individualized particles in suspension. Flow cytometers use lasers as a source of light excitation; therefore, it must be possible to label the particles with one or more fluorescent substances. Information is also collected on the size and structural complexity of each particle. This multiparametric study of each particle allows us to analyze subpopulations in complex samples using an electronic classification. Some cytometers are also equipped with modules for classifying and collecting particles of interest. The most important applications of flow cytometry include those related to the study of cell surface receptors, nuclear and cytoplasmic antigens, DNA content, enzymatic activity, cell integrity, and membrane permeability and flow. kicks. The cytometry platform has a wide range of flow cytometry and cell separation applications, and develops or implements new ones based on the demand of researchers. Its use has become widespread in the field of biomedicine (Hematology, Immunology, Pharmacology, Oncology, Microbiology, Genetics, etc.).

GINYS-IISPV-001

Biobank IISPV

The IISPV Biobank is an institutional and centralized platform of transversal services: processing, storage, management and distribution of human biological samples for IISPV researchers and also for researchers or other external personnel that may require them. services. The Biobank is made up of two biocans: the Biobank of the Joan 23 University Hospital and the IISPV (with three nodes: Tarragona, Reus and Tortosa)

Development and evaluation of a novel advanced lipoprotein test based on 2D Diffusion-ordered 1H NMR Spectroscopy

Roger Mallol Parera