
UAT – Metabolomics
Main Contacts
RP
Institutional Contacts / Head of Facilities
MR
Provisional Contacts
CERCA Institutes

Barcelona, Spain
2002
Vall d’Hebron Institut de Recerca (VHIR)
Owners
VHIR
Equipments & Services Offered
Waters ACQUITY Ultra Performance LC assembled with an MS / MS Xevo TQ spectrometer (Waters). This station is also equipped with two additional detectors: ultraviolet / visible and fluorescence. Other mass spectrometers are available at the Vall d’Hebron Campus to develop customized proteomics projects, both directed and non-directed. In addition, there are massive specifications dedicated to clinical applications.
Development of analytical methods for the detection and quantification of endogenous and exogenous analytes in biological substrates (ie, serum, urine, plasma, cerebrospinal fluid, cell tissues and cultures). Methodological support for self-service users. There is also assistance with experimental design, implementation of new protocols and analysis and interpretation of data APLICATIONS Chromatographic and spectroscopic techniques provide great sensitivity compared to NMR (femtomol detection limit) and allow the detection of about 4000 different substances. Some examples of determinations that have been made on the platform are: Vitamins (i.e., D2 and D3) and serum phytoestrogens Determination of intermediate and final metabolites of different metabolic pathways Pharmacokinetic studies and determination of drugs in biological fluids and tissues Amino acids in urine, serum and cerebrospinal fluid Plasma or serum lipids Drug determination in nanoparticle release studies Efficiency of drug encapsulation in nanoparticles Determination of endogenous metabolites and drugs in samples of dry blood stains (DBS). Stability studies of biological drugs
Categorització
RIS3CAT domains & other
Social and Health System
Industrial System
Educational and knowledge generation System
TECHNOLOGICAL EQUIPMENT
Metabolomics
GINYS-VHIR-005
Access procedure & Fares
Institutional Quality
Institutional Networks